Annexin V at the Nexus of Immune Tolerance, Apoptosis, an...

2025-10-21

This thought-leadership article explores Annexin V's mechanistic power as a phosphatidylserine binding protein for apoptosis detection, with a strategic lens for translational researchers investigating immune regulation, cell death, and disease modeling. Integrating recent findings on immune cell apoptosis and immune tolerance disruptions in preeclampsia, we chart a roadmap for leveraging Annexin V beyond conventional assays—toward innovative immune-imbalance models, high-content screening, and clinical translation. This piece escalates the field by connecting molecular insight to actionable strategies, referencing pivotal studies and internal resources.